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Understanding the Genetic Role in Weight Gain
Gaining and maintaining weight is not solely a matter of diet and activity level. Genetics significantly influences how the body stores fat, regulates hunger, and processes nutrients for many individuals. Research shows that genetics can impact a person’s susceptibility to obesity by affecting factors like metabolism, hormone regulation, fat distribution, and appetite.
While making healthy lifestyle choices is always encouraged, some may find that these efforts alone do not yield lasting results. It can be frustrating, especially for those who feel they’re doing everything “right” and still not achieving their weight loss goals. That’s where medical weight loss programs, like those offered at Lips and Drips, can make a meaningful difference, especially when supported by medications such as Semaglutide.
Genetics and Weight—What Science Tells Us
Not everyone gains weight in the same way or at the same rate. Some individuals have genetic traits that make them more likely to gain weight, even following a balanced lifestyle. Key genetic factors that contribute to weight gain include:
Metabolic Rate
Your metabolism controls how your body converts food into energy. Some people are genetically predisposed to slower metabolisms, so they burn fewer calories at rest and during activity. This can make weight loss more challenging, even with consistent effort.
Hormonal Influences
Hormones like insulin, ghrelin, and leptin regulate hunger and fat storage. Genetic variations can alter how these hormones behave, influencing appetite and satiety. For instance, some people may feel hungry more often due to increased ghrelin production or have trouble feeling full due to leptin resistance.
Fat Storage and Distribution
Genetic factors also influence where your body stores fat—whether around the midsection, hips, or thighs. Central obesity (fat stored around the waist) is particularly associated with higher health risks and is often genetically influenced.
Family History of Obesity
If your close family members struggle with obesity or related health issues, it’s more likely that you may also face similar challenges. These inherited tendencies can influence how your body responds to diet and physical activity.
These genetic predispositions are not a sentence but a signal that a different approach may be necessary, especially when achieving meaningful, long-term weight loss.
Why Diet and Exercise Alone May Not Be Enough
For individuals with a strong genetic tendency toward obesity, traditional methods like calorie restriction and physical activity may only lead to minimal changes. This isn’t due to a lack of effort—it’s a sign that the body may require additional support.
In these cases, a structured medical weight loss program with professional oversight can be an effective next step. These programs combine behavioral support, lifestyle recommendations, and medical treatments like Semaglutide weight loss therapy to offer better results than lifestyle changes alone.
Lips and Drips offers evidence-based, physician-guided treatment plans in Philadelphia, PA, for individuals ready to address the root causes of weight gain and get real, lasting support.
What Is Semaglutide and How Does It Work?
Semaglutide is an injectable medication that is FDA-approved to treat overweight and obesity-related health concerns. It is part of a class of medications known as GLP-1 receptor agonists, which mimic the body’s natural hormone glucagon-like peptide-1 (GLP-1).
How GLP-1 Supports Weight Management
GLP-1 plays several roles in blood sugar regulation and appetite control. Semaglutide activates GLP-1 receptors, which help in:
- Reducing appetite and food cravings
- Slowing down stomach emptying, so you feel full longer
- Enhancing insulin sensitivity and regulating blood sugar
- Decreasing the brain’s reward response to food
These effects make Semaglutide an effective appetite suppressant therapy. In clinical trials, Semaglutide patients experienced significant weight loss compared to those using lifestyle modifications alone.
Medical Weight Loss in Philadelphia: Who Should Consider Semaglutide?
At Lips and Drips, patients seeking weight loss in Philadelphia, PA, often ask if Semaglutide is right for them. This treatment is generally recommended for:
- Those with a body mass index (BMI) greater than 30 higher
- Adults with a BMI of 27 or higher and at least one weight-related health condition (such as hypertension or type 2 diabetes)
- People who have had difficulty losing weight through diet and exercise
If you meet these criteria, our team will perform a comprehensive evaluation to determine whether Semaglutide fits into your customized medical weight loss plan. It involves examining your medical history, lifestyle habits, genetic factors, and weight loss goals.
What to Expect During Semaglutide Weight Loss Treatment
Initial Consultation and Evaluation
Treatment begins with a thorough assessment. This includes:
- Medical history review
- Lab work (as needed)
- BMI and body composition measurements
- A discussion of lifestyle and health goals
This step helps ensure that Semaglutide is safe and suitable for you. It also allows the provider to develop a tailored treatment plan including lifestyle support and medication.
Ongoing Support
Once prescribed, Semaglutide is administered weekly through a small injection, which patients can self-administer at home. Patients are monitored regularly for progress, side effects, and overall well-being. Adjustments can be made to dosage or supportive therapies as needed.
Complementary Lifestyle Changes
Medication is just one part of the treatment. At Lips and Drips, we support patients with nutrition advice, physical activity recommendations, and behavior coaching. This comprehensive approach improves long-term outcomes and builds lasting healthy habits.
Is Semaglutide Safe? What Are the Side Effects?
Most patients tolerate Semaglutide well, especially when the dosage is increased gradually under medical supervision. It is important to note, however, that side effects can occur. The most common include:
- Nausea
- Constipation or diarrhea
- Fatigue
- Mild abdominal discomfort
These effects often lessen over time as your body adjusts. Our medical team at Lips and Drips closely monitors every patient and provides strategies to manage side effects, ensuring your safety and comfort throughout the program.
Semaglutide is not recommended for individuals with a personal or family history of certain thyroid conditions or those with specific gastrointestinal disorders. A full consultation will help identify any potential concerns.
Combining Genetic Awareness with Modern Obesity Treatment Options
Understanding how genetics affects your weight helps take the guilt and guesswork out of the equation. If your body is genetically inclined to store fat, has irregular appetite signals, or processes sugar differently, it doesn’t mean you’ve failed—it means you need a medical approach that considers your biology.
Semaglutide weight loss treatment provides one of today’s most promising tools for individuals seeking GLP-1 weight management support. When used as part of a medical weight loss program, it offers a structured and realistic path forward, especially for those who’ve tried conventional options without success.
Whether you’re looking to manage chronic weight gain or need help overcoming weight-related health risks, professional care from Lips and Drips ensures that your program is medically sound, individualized, and achievable.
Ready for a Change? Get Expert Help for Your Weight Loss Goals
If you’ve struggled with weight gain and suspect that genetics may be playing a role, you’re not alone—and you don’t have to face it without support. At Lips and Drips, we offer science-based solutions like Semaglutide weight loss therapy to help you confidently move forward. Our team is here to guide you through every step of your weight loss in Philadelphia, PA, with personalized treatment plans and expert medical care.
Ready to take control of your weight? Schedule your Semaglutide consultation today and start your journey toward lasting results. For more information, contact Lips and Drips to speak with our professional care team member.
